PC Maintenance
Run anti-virus scan on a daily basis.
Check for updates to anti-virus and anti-spyware software for the latest virus definitions, and run a scan.
Make a backup copy of all critical data.
Check that you have enough free disk space.
Remove any applications you don't need.
Use a clean up tool to clear out cached and temporary files.
Remove unnecessary startup programs.
Periodically empty the recycle bin.
Defragment all drives.
Change all passwords periodically to protect yourself against identity theft.
Check all PC cables are correctly plugged in securely.
Create or update the boot disk.
Make sure the hardware works.
Hardware Maintenance
Turn your PC off and unplug it.
Open up the case of your PC.
Use canned air to blow away the accumulated dirt and dust.
Be sure to blow the dust out from a variety of angles, to be sure you clean out the hidden areas.
Remove dust from all fans.
To loosen debris and grime use foam rubber swabs.
Do not to use brushes, cotton swabs, or pieces of cloth, because they can leave a residue and produce static charges.
Do not use any kind of fluid at all, cleaning fluid or otherwise.
Clear dust and grime accumulated in your power supply by spraying air through all the supply's vent openings.
Spray the cable connections.
Spray between the cracks of the keyboard.
Turn the keyboard upside down to enable the particles to fall out.
Clean the monitor with a screen cleaner that counters static buildup.

PC Maintenance Checklist

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